For patients with HAE attacks...

RUCONEST provided symptom relief that lasted

HAE symptom relief visually demonstrated in a clinical study participant over a 24-hour periodb

In the study, patients were required to be experiencing a moderate to severe HAE attack for less than 5 hours prior to the start of RUCONEST therapy.

1 hour prior to dosing

Time of dosing

30 mins post-dose

60 mins post-dose

2 hours post-dose

4 hours post-dose

8 hours post-dose

24 hours post-dose

RUCONEST successfully treated this attack with just 1 dose

bThis is an actual patient. Individual results may vary.

  • In the primary clinical study, patients treated with RUCONEST started to see symptom relief in 90 minutes vs 152 minutes with placebo
  • In an extension of the study, patients started to see symptom relief in 75 minutes

RUCONEST once-and-done dosing

  • 89% of patients needed just one 50 IU/kg dose
    of RUCONEST per attack in a clinical study
  • 97% of attacks needed just one 50 IU/kg dose
    in an extension of the clinical study

RUCONEST: Once-and-done dosing

Raffi Tachdjian, MD

UCLA School of Medicine, Los Angeles, CA

Most RUCONEST patients were symptom-free for at least 3 days

  • As shown in a review of studies that included 68 patients (280 attacks)

RUCONEST addresses the root cause of HAE attacks

Most people with HAE don't have enough C1-INH

HAE is caused by not having enough of the blood protein called C1-INH, or by C1-INH that isn’t working properly.

RUCONEST works by increasing functional C1-INH levels in the blood into the normal range. RUCONEST also helps stop the production of kallikrein, an enzyme that activates bradykinin, which causes blood vessels to leak and certain parts of the body to swell.

How RUCONEST works

How RUCONEST works

Daniel Soteres, MD

Asthma & Allergy Associates, Colorado Springs, CO

RUCONEST raised functional C1-1NH levels to normal in 94% of patients

RUCONEST has a well-established tolerability profile

Adverse reactions occurring in 2% of patients treated for an acute attack in 7 studies

All RUCONEST dosesc
205 total patients treated

Headache

19 patients (9%)

Nausea

5 patients (2%)

Diarrhea

5 patients (2%)

cIncluded doses up to 100 IU/kg.

What does plasma-free mean?

Daniel Soteres, MD

Asthma & Allergy Associates, Colorado Springs, CO

  • The serious adverse reaction in clinical studies of RUCONEST was anaphylaxis
  • Who should not use RUCONEST?
  • You should not use RUCONEST if you have a known or suspected allergy (hypersensitivity) to rabbits or rabbit-derived products.

    You should not use RUCONEST if you have experienced life-threatening immediate hypersensitivity reactions, including anaphylaxis, to RUCONEST or to any other C1 esterase inhibitor product.

    RUCONEST is not indicated for use in children under the age of 13 years.

  • Rabbit allergy testing is not required

Pregnancy category B classificationd

dRUCONEST has not been studied in pregnant women; therefore it should only be used during pregnancy if clearly needed. Notify your physician if you are breastfeeding or plan to breastfeed.

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