RUCONEST gives you the symptom relief you need—when you need it
RUCONEST is a C1 esterase inhibitor, or C1-INH, indicated for the treatment of acute attacks in adult and adolescent patients with HAE.
A PLASMA-FREE C1-INH, which has no risk of passing on human viruses
Rapid onset of relief, with a median time of 75 to 90 minutes
Approximately 9 of 10 people needed JUST ONE DOSE
Symptom relief lasted for at least 3 days in 93% of attacksa
There is a RELIABLE SUPPLY of RUCONEST
aAs shown in a review of studies that included 68 patients (280 attacks).
Hear why Dr Bernstein has confidence in RUCONEST
Jonathan A. Bernstein, MD
University of Cincinnati and Partner at
Bernstein Allergy Group, Inc., Cincinnati, OH
For patients with HAE attacks...
RUCONEST provided symptom relief that lasted
HAE symptom relief visually demonstrated in a clinical study participant over a 24-hour periodb
In the study, patients were required to be experiencing a moderate to severe HAE attack for less than 5 hours prior to the start of RUCONEST therapy.
1 hour prior to dosing
Time of dosing
30 mins post-dose
60 mins post-dose
2 hours post-dose
4 hours post-dose
8 hours post-dose
24 hours post-dose
RUCONEST successfully treated this attack with just 1 dose
bThis is an actual patient. Individual results may vary.
In the primary clinical study, patients treated with RUCONEST started to see symptom relief in 90 minutes vs 152 minutes with placebo
In an extension of the study, patients started to see symptom relief in 75 minutes
RUCONEST once-and-done dosing
89% of patients needed just one 50 IU/kg dose of RUCONEST per attack in a clinical study
97% of attacks needed just one 50 IU/kg dose in an extension of the clinical study
RUCONEST: Once-and-done dosing
Raffi Tachdjian, MD
UCLA School of Medicine, Los Angeles, CA
Most RUCONEST patients were symptom-free for at least 3 days
As shown in a review of studies that included 68 patients (280 attacks)
RUCONEST addresses the root cause of HAE attacks
Most people with HAE don't have enough C1-INH
HAE is caused by not having enough of the blood protein called C1-INH, or by C1-INH that isn’t working properly.
RUCONEST works by increasing functional C1-INH levels in the blood into the normal range. RUCONEST also helps stop the production of kallikrein, an enzyme that activates bradykinin, which causes blood vessels to leak and certain parts of the body to swell.
How RUCONEST works
How RUCONEST works
Daniel Soteres, MD
Asthma & Allergy Associates, Colorado Springs, CO
RUCONEST raised functional C1-INH levels to normal in ≥94% of patients
RUCONEST has a well-established tolerability profile
Adverse reactions occurring in ≥2% of patients treated for an acute attack in 7 studies
All RUCONEST dosesc 205 total patients treated
Headache
19 patients (9%)
Nausea
5 patients (2%)
Diarrhea
5 patients (2%)
cIncluded doses up to 100 IU/kg.
What does plasma-free mean?
Daniel Soteres, MD
Asthma & Allergy Associates, Colorado Springs, CO
The serious adverse reaction in clinical studies of RUCONEST was anaphylaxis
Who should not use RUCONEST?
You should not use RUCONEST if you have a known or suspected allergy (hypersensitivity) to rabbits or rabbit-derived products.
You should not use RUCONEST if you have experienced life-threatening immediate hypersensitivity reactions, including anaphylaxis, to RUCONEST or to any other C1 esterase inhibitor product.
RUCONEST is not indicated for use in children under the age of 13 years.
Rabbit allergy testing is not required
Pregnancy category B classificationd
dRUCONEST has not been studied in pregnant women; therefore it should only be used during pregnancy if clearly needed. Notify your physician if you are breastfeeding or plan to breastfeed.
