Dosing & Administration I RUCONEST Treatment for HAE Attacks

How to self-administer RUCONEST

Watch the video below to see Noah prepare and self-administer his dose of RUCONEST. Be sure to read the full instructions, located in the Prescribing Information under the Patient Product Information section, before preparing the medication for injection.

To help you become comfortable with self-administration, a dedicated RUCONEST Patient Advocate Nurse is available to you for in-person training, as many times as needed.

Watch the self-administration video

Noah, 13 years old

Taking RUCONEST to treat HAE

RUCONEST dosing and administration

Recommended dose of RUCONEST for an acute attack

Discuss dosing with your healthcare provider to help ensure that the correct dose of RUCONEST is administered.

Dosing by body weight

Body weight^a

RUCONEST dose for IV injection

Volume (mL) of reconstituted solution (150 IU/mL) to be administered

<84 kg (185 lb)

50 IU per kg

Body weight in kg divided by 3

≥84 kg (185 lb)

4200 IU (2 vials)

28 mL

^a1 kg=2.2 lb

How to administer RUCONEST

RUCONEST is administered by slow intravenous (IV) injection over approximately 5 minutes
Patients may self-administer RUCONEST after receiving appropriate training by a qualified healthcare professional
RUCONEST should be administered upon recognition of an HAE attack

The importance of vein care

Tips to ensure optimal vein health for patients self-administering RUCONEST

RUCONEST can be self-administered by appropriately trained patients, so it's important that you do everything you can to take care of your veins. Below are some tips to help keep your veins healthy and viable.

Vein Care Dos:

Find a well-lit area to do your infusion
Make sure to alternate arms when infusing your RUCONEST doses
When choosing a vein, look for one that feels bouncy, not stiff or rolling!
Use a tourniquet to apply pressure and help your vein become more prominent for easier access
Stay hydrated

Vein Care Don'ts:

Don't rush. Staying calm will help you to easily access your veins
Don't use veins that are red, inflamed, or sore to touch
Don't forget to remove the tourniquet. Leaving it on for a long time may cause damage to your veins

Important Note: Veins that are red or inflamed may be a sign of infection. Infusing with an infected vein may cause permanent damage. Talk to your healthcare provider about what you can do to treat red or inflamed veins

Why RUCONEST?

RUCONEST is a plasma-free C1-INH proven to help treat HAE attacks.

Learn more

Preparing for Your Visit

Prepare for a visit with your healthcare provider with this helpful discussion guide.

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Resources and Support

RUCONEST SOLUTIONS is a program available to support you throughout your treatment journey.

Learn more

INDICATION (USES)

What is RUCONEST?

RUCONEST is an injectable medicine that is used to treat acute angioedema attacks in adult and adolescent patients with Hereditary Angioedema (HAE).

IMPORTANT SAFETY INFORMATION

Who should not use RUCONEST?

You should not use RUCONEST if you have a known or suspected allergy (hypersensitivity) to rabbits or rabbit-derived products.

You should not use RUCONEST if you have experienced life-threatening immediate hypersensitivity reactions, including anaphylaxis, to RUCONEST or to any other C1 esterase inhibitor product.

RUCONEST is not indicated for use in children under the age of 13 years.

What should I tell my healthcare provider before using RUCONEST?

Tell your healthcare provider about all of your medical conditions, including if you:

have an allergy to rabbits since this can put you at high risk of a serious allergic reaction with RUCONEST. These allergy symptoms could include runny nose, itchy nose, sneezing, coughing, wheezing, difficulty breathing or watery eyes when you are near rabbits.
are pregnant or planning to become pregnant. It is not known if RUCONEST can harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if RUCONEST passes to your milk or if it can harm your baby.

Tell your healthcare provider and pharmacist about all of the medicines you take, including all prescription and non-prescription medicines such as over-the-counter medicines, supplements, or herbal remedies.

How is RUCONEST given?

RUCONEST will be dissolved in sterile water and slowly injected into your vein (intravenous injection). Most of the time a single dose of RUCONEST is enough to treat an attack, but a second dose may be needed.

What are the possible effects of RUCONEST?

Allergic reactions may occur with RUCONEST. Call your healthcare provider or the emergency department immediately if you have any of the following symptoms after receiving RUCONEST: wheezing, difficulty breathing, chest tightness, turning blue (look at lips and gums), fast heartbeat, swelling, faintness, rash or hives.

In clinical studies, the most severe side effect reported was a severe allergic reaction in a subject who was allergic to rabbits.

Other side effects patients experienced during clinical studies include:

headache
nausea
diarrhea

These are not all the possible side effects of RUCONEST.
If any of the side effects get serious, or if you notice any side effects not listed here, please inform your healthcare provider or pharmacist. You can also report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

For product information, adverse event reports, and product complaint reports, please contact Pharming U.S. toll-free:

(844) 474-2764 Main corporate number

(800) 930-5221 Pharmacovigilance, product complaints, medical information

Please click here for full Prescribing Information, including Patient Product Information.