Signs and symptoms of an HAE swell

HAE attacks can occur anywhere on the body, and vary in length and severity. Therefore, it is important to treat HAE at the first sign of a swell.

Because all swells are not visible, it is important to learn to recognize the early signs that a swell may be coming. These differ from person to person and may include:

HAE attack symptom: fatigue

Fatigue

HAE attack symptom: rash

Rash

HAE attack symptom: stomach upset

Stomach upset

HAE attack symptom: headache

Headache

HAE attack symptom: stomach cramps

Difficulty swallowing and breathing

HAE attack symptom: numbness or tingling

Numbness or tingling

HAE attack symptom: muscle and joint pain

Muscle and joint pain

Just one dose of RUCONEST can get you back to things that matter

  • 97%One and Done – 97% of acute swells were treated with JUST 1 DOSE*
  • 93%Relief That Lasts – Stopped 93% of attacks for at least 3 days†
  • 85%Confident Dosing – 85% of patients were confident self-administering‡

How RUCONEST is helping Sophie manage her swells

*50 U/kg (max 4200 U) in clinical studies (open-label extension phase, n=44 [170 attacks]).
†As shown in a review of studies that included 68 people (280 attacks).
‡Data from 601 patients using RUCONEST show that 85% of patients trained felt confident, mostly confident, or extremely confident on a Likert scale of 1-5 in terms of their ability to self-infuse.

Work with your healthcare provider to manage your swells

It's important to treat your HAE at the earliest signs of a swell. Talk to your doctor about your swells and what you can do to manage them.

Bring this guide to your next healthcare appointment.

Download Discussion Guide
"Having a list of questions to ask my doctor helps me feel more empowered to understand and take control of my HAE."

— Corey, living with HAE

Experience the benefits of one-and-done dosing with RUCONEST

If you are treating the same swell multiple times, speak to your doctor about a change. RUCONEST may be able to help you get back to things that matter. RUCONEST replaces the missing or nonworking C1-INH to stop an HAE swell.
HAE attack symptom: fatigue
  • 9 of 10 patientsachieved symptom relief in the pivotal clinical trial with just 1 dose (n=44)*
  • In the primary clinical study, patients saw symptom relief in 90 minutes vs 152 minutes with placebo*
  • In the extension study, symptom relief began in 75 minutes*

*50 U/kg (max 4200 U) in clinical studies (open-label extension phase, n=44 [170 attacks]).

RUCONEST offered relief that lasts

Your acute treatment should work with just 1 dose and provide you relief that lasts.
HAE attack symptom: fatigue
*As shown in a review of studies that included 68 people (280 attacks). Based on a post hoc analysis of pooled data from the randomized controlled study and open-label extension phases of 2 studies involving 127 patients aged 13 years who were treated with RUCONEST 50 U/kg (max 4200 U) for acute attacks of HAE. Data for 72 hours were available for 68 of 127 patients.

RUCONEST has a well-established tolerability profile

RUCONEST has a well-established tolerability profile. Adverse reactions in ≥2% of patients in 7 studies (all RUCONEST doses up to 100 U/kg) included:

HAE attack symptom: fatigue

Headache9% (19 of 205 patients)

HAE attack symptom: fatigue

Nausea2% (5 of 205 patients)

HAE attack symptom: fatigue

Diarrhea2% (5 of 205 patients)


You can confidently administer RUCONEST

Confidently administer RUCONEST after training
  • RUCONEST is portable and can be self-administered after training*
  • Prior to reconstitution RUCONEST does not need to be refrigerated
  • After reconstitution, RUCONEST is injected over 5 minutes with a small butterfly needle

*Initial training will be under the supervision of an HCP experienced in the treatment of HAE.

†Data from 601 patients using RUCONEST show that 85% of patients trained felt confident, mostly confident, or extremely confident on a Likert scale of 1-5 in terms of their ability to self-infuse.

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