Signs and symptoms of an HAE swell

HAE attacks can occur anywhere on the body, and vary in length and severity. Therefore, it is important to treat HAE at the first sign of a swell.

Because all swells are not visible, it is important to learn to recognize the early signs that a swell may be coming. These differ from person to person and may include:

HAE attack symptom: fatigue

Fatigue

HAE attack symptom: rash

Rash

HAE attack symptom: stomach upset

Stomach upset

HAE attack symptom: headache

Headache

HAE attack symptom: stomach cramps

Difficulty swallowing and breathing

HAE attack symptom: numbness or tingling

Numbness or tingling

HAE attack symptom: muscle and joint pain

Muscle and joint pain

RUCONEST can be used at the first sign of a swell

  • RUCONEST, a C1-inhibitor, replaces the missing or nonworking C1-INH to stop an HAE swell before it fully develops
  • US HAEA Medical Advisory Board 2020 Guidelines state early treatment is important to prevent swell progression, no matter how severe. After self-administered treatment, you should seek medical care if the attack involves the airway.

What events can trigger an HAE swell?

Even though swells may occur without a clear trigger, it's important to recognize some common triggers that can lead to an attack, such as:

  • Anxiety
  • Stress
  • Minor injuries
  • Surgical or dental procedures
  • Certain medications (e.g., estrogen-containing birth control medications)
  • Infections
  • Hormonal changes, such as those occurring during pregnancy or menstruation

Create a treatment plan with your healthcare provider

Even if you are taking preventative treatment, you should always have at least 2 doses of on-demand treatment on hand at all times to treat HAE swells when they occur.

Bring this guide to your next healthcare appointment.

"Having a list of questions to ask my doctor helps me feel more empowered to understand and take control of my HAE."

— Corey, living with HAE

Experience the benefits of one-and-done dosing with RUCONEST

If you are treating the same swell multiple times, speak to your doctor about a change. RUCONEST may be able to help you get back to things that matter. RUCONEST replaces the missing or nonworking C1-INH to stop an HAE swell.
HAE attack symptom: fatigue
  • 9 of 10 patientsachieved symptom relief in the pivotal clinical trial with just 1 dose (n=44)*
  • In the primary clinical study, patients saw symptom relief in 90 minutes vs 152 minutes with placebo*
  • In the extension study, symptom relief began in 75 minutes*

*50 U/kg (max 4200 U) in clinical studies (open-label extension phase, n=44 [170 attacks]).

RUCONEST offered relief that lasts

Your acute treatment should work with just 1 dose and provide you relief that lasts.
HAE attack symptom: fatigue
*As shown in a review of studies that included 68 people (280 attacks). Based on a post hoc analysis of pooled data from the randomized controlled study and open-label extension phases of 2 studies involving 127 patients aged 13 years who were treated with RUCONEST 50 U/kg (max 4200 U) for acute attacks of HAE. Data for 72 hours were available for 68 of 127 patients.

RUCONEST has a well-established tolerability profile

RUCONEST has a well-established tolerability profile. Adverse reactions in ≥2% of patients in 7 studies (all RUCONEST doses up to 100 U/kg) included:

HAE attack symptom: fatigue

Headache9% (19 of 205 patients)

HAE attack symptom: fatigue

Nausea2% (5 of 205 patients)

HAE attack symptom: fatigue

Diarrhea2% (5 of 205 patients)


You can confidently administer RUCONEST

Confidently administer RUCONEST after training
  • RUCONEST is portable and can be self-administered after training*
  • Prior to reconstitution RUCONEST does not need to be refrigerated
  • After reconstitution, RUCONEST is injected over 5 minutes with a small butterfly needle

*Initial training will be under the supervision of an HCP experienced in the treatment of HAE.

†Data from 601 patients using RUCONEST show that 85% of patients trained felt confident, mostly confident, or extremely confident on a Likert scale of 1-5 in terms of their ability to self-infuse.

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