What is HAE? I RUCONEST Treatment for HAE Attacks

HAE is an unpredictable and disruptive disease

Understanding HAE

Whether you have just been diagnosed, or have been living with HAE for some time, it’s important to understand the disease and to be prepared for your next attack.

HAE causes repeated episodes of swelling that can occur at any time, and in almost any part of the body. HAE is not an allergy or allergic reaction. It is a disease that may be inherited, but can also occur without any family history. People with HAE tend to experience their first attack early in life, with symptoms increasing around puberty.

Hear a patient story

Daniel Soteres, MD

Asthma & Allergy Associates, Colorado Springs, CO

Some of the causes of HAE include:

Not having enough of a blood protein called C1-INH
C1-INH that isn't working properly

Having enough working C1-INH in the blood prevents the chain of events that lead to symptoms of an attack.

HAE attacks can be painful and disrupt normal daily life. Fortunately, there are effective treatments that can help

Treat HAE at the first sign or symptom of an attack

HAE attacks can occur anywhere on the body, and vary in length and severity. Therefore, it is important to treat HAE at the first sign of an attack.

Learn to recognize the early signs that an attack may be coming. These vary from person to person and may include:

Fatigue

Rash

Stomach upset

Muscle and joint pain

Stomach cramps

Numbness or tingling

Headache

Many HAE attacks occur without an obvious "trigger." However, you may also come to recognize certain events as triggers. These may include:

Anxiety
Stress
Minor injuries
Dental procedures
Medications
Infections
Hormonal changes, such as those occurring during pregnancy or menstruation

Symptoms and triggers

Daniel Sotores, MD

Asthma & Allergy Associates, Colorado Springs, CO

Have a plan to treat your HAE attacks

In addition to being aware of the warning signs of an attack, you should have a treatment plan in place to address each HAE attack as soon as it occurs.

Work with your healthcare provider to ensure that you have a treatment plan ready and therapy available so you’ll be prepared to treat your next HAE attack.

HAE advocacy

If you're suffering from HAE, there is an organization working diligently to make sure you know you're not alone

The US Hereditary Angioedema Association (HAEA) is a nonprofit patient advocacy organization dedicated to serving people with angioedema. They provide patients and families with a support network and a wide range of services.

Preparing for Your Visit

Prepare for a visit with your healthcare provider with this helpful discussion guide.

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Why RUCONEST?

RUCONEST is a plasma-free C1-INH proven to help treat HAE attacks.

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WHAT IS RUCONEST?

Ruconest is an injectable prescription medicine that is used to treat acute attacks of hereditary angioedema (HAE) in adult and adolescent patients over the age of 12.

IMPORTANT SAFETY INFORMATION

Do not use RUCONEST if you have experienced life-threatening immediate hypersensitivity reactions, including anaphylaxis, to RUCONEST or to any other C1 esterase inhibitor (C1-INH) product. Call your healthcare professional or the emergency department right away if you experience: wheezing, difficulty breathing, chest tightness, turning blue (look at lips and gums), fast heartbeat, swelling, faintness, rash or hives.

Do not use RUCONEST if you have a known or suspected allergy to rabbits or rabbit-derived products. If you do not have a known rabbit allergy, testing is not required.

Tell your healthcare provider about all your medical conditions, including if you have a known allergy to rabbits. Tell your healthcare provider about any other medications you are taking, as some medications, such as birth control pills and certain androgens, can increase risk of clotting problems. Also tell your healthcare provider if you are pregnant, breastfeeding, or planning to do so.

The most common side effects patients experienced during clinical studies include headache, nausea and diarrhea. These are not all the possible side effects of RUCONEST.

If any of the side effects get serious, or if you notice any side effects not listed here, please inform your healthcare provider or pharmacist. You can also report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

For product information, adverse event reports, and product complaint reports, please contact Pharming U.S. toll-free:

(844) 474-2764 Main corporate number

(800) 930-5221 Adverse events, product complaints, medical information

Please read the full Prescribing Information, including Patient Product Information by clicking here.