Signs and Symptoms of an HAE Attack

HAE attacks can occur anywhere on the body, and vary in length and severity. Therefore, it is important to treat HAE at the first sign of an attack.

Learn to recognize the early signs that an attack may be coming. These vary from person to person and may include:

HAE attack symptom: fatigue


HAE attack symptom: rash


HAE attack symptom: stomach upset

Stomach upset

HAE attack symptom: muscle and joint pain

Muscle and joint pain

HAE attack symptom: stomach cramps

Stomach cramps

HAE attack symptom: numbness or tingling

Numbness or tingling

HAE attack symptom: headache


What Triggers Hereditary Angioedema?

Many HAE attacks occur without an obvious "trigger." However, you may also come to recognize certain events as triggers. These may include:

  • Anxiety
  • Stress
  • Minor injuries
  • Dental procedures
  • Medications
  • Infections
  • Hormonal changes, such as those occurring during pregnancy or menstruation

Symptoms and triggers

Daniel Sotores, MD

Asthma & Allergy Associates, Colorado Springs, CO

Have a plan to treat your HAE attacks

In addition to being aware of the warning signs of an attack, you should have a treatment plan in place to address each HAE attack as soon as it occurs.

Work with your healthcare provider to ensure that you have a treatment plan ready and therapy available so you’ll be prepared to treat your next HAE attack.

HAE advocacy

If you're suffering from HAE, there is an organization working diligently to make sure you know you're not alone

HAE advocacy groups

The US Hereditary Angioedema Association (HAEA) is a nonprofit patient advocacy organization dedicated to serving people with angioedema. They provide patients and families with a support network and a wide range of services.

Preparing for Your Visit

Prepare for a visit with your healthcare provider with this helpful discussion guide.

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RUCONEST is a plasma-free C1-INH proven to help treat HAE attacks.

Learn more