For most patients RUCONEST offered durable symptom relief for at least 3 days 3

RUCONEST stopped 93% of attacks for at least 3 days. As shown in a review of studies that included 68 people (280 attacks)
As shown in a review of studies that
included 68 people (280 attacks) 3

Most patients had no HAE symptom relapse for at least 3 days* 3

*Based on a post hoc analysis of pooled data from the randomized controlled study and open-label extension phases of 2 studies involving 127 patients aged 13 years who were treated with RUCONEST 50 U/kg (max 4200 U) for acute attacks of HAE. Data for 72 hours were available for 68 of 127 patients.

An acute therapy for your HAE patients

Michael Manning, MD
Diplomate American Board of Internal Medicine,
Diplomate American Board of Allergy and Immunology

RUCONEST normalized C1-INH levels in 94% of patients

RUCONEST used the optimal dose to normalize C1-INH levels in 94% of study participants 4

Maximum functional C1-INH concentrations after one dose of RUCONEST 1

Observed maximum functional C1-INH (U/kg) greater than or equal to 94% at 50 U/kg dose.
  • In a dose ranging study of RUCONEST, 50 U/kg was identified as the optimal dose 5
  • RUCONEST provides 100% bioavailability; the C1-INH gets to the site of action immediately 5
Corey a patient speaker states "I reach for my Ruconest first over other acute medicines because it works for me." Patient permission was granted for this quote

RUCONEST has a well-established tolerability profile 1

In clinical trials, the most common adverse events were

In clinical trials, the most common adverse events were headache 9%, nausea 2%, and diarrhea 2%.
  • Adverse reactions in 2% of patients in RCT and OLE studies (N=205)
  • In clinical trials, the most serious adverse reaction was anaphylaxis

RUCONEST is contraindicated in patients with a history of allergy to rabbits or rabbit-derived products, and patients with a history of life-threatening immediate hypersensitivity reactions to C1 esterase inhibitor preparations, including anaphylaxis.

Rabbit allergy testing is not required.

*Included doses up to 100 U/kg.
RCT=randomized controlled trial; OLE=open-label extension.

Ongoing training and education increased patients' confidence 5

Approximately 85% of over 600 patients were confident in self-injecting Ruconest. Injection is done over 5 minutes by a small 23-gauge butterfly needle
~85% of over 600 patients were
confident in self injecting RUCONEST 5*
Injection is done over 5 minutes by a small
23-gauge butterfly needle

RUCONEST Patient Advocates (RPAs) are Clinical Educators who do not provide nursing services, medical advice, or treatment advice. RPAs do not sell, market, or promote RUCONEST.

*Data from 601 patients using RUCONEST show that ~85% of patients trained feel somewhat confident, mostly confident, or extremely confident on a Likert scale from 1-5 in terms of their ability to self-infuse.

Introduce your patients to Vein Finder, a tool to help them self-inject.

It is important that your patients treat HAE at the first sign of an attack. RUCONEST SOLUTIONS provides access to a variety of IV injection tools that can help support long-term self-administration of RUCONEST.

Relatively painless with proper technique

Vein Finders are available on loan for eligible RUCONEST patients:

  • Designed to help patients find veins and improve first-stick success
  • Allow patients to rotate injection sites to help keep veins healthy

picture of vein finder with stand

RUCONEST allows appropriately trained patients and their caregivers to treat attacks at home or on the go

RUCONEST is injected over
5 minutes with a small, 23-
gauge butterfly needle 1
Prior to reconstitution,
RUCONEST does not
need to be refrigerated 1
Prior to reconstitution,
RUCONEST has a 4-year shelf
life when stored at room
temperature (36º-77ºF) 1

RUCONEST may be a good option for women, including for women of childbearing age*

According to a National Survey of Family Growth, ~50% of pregnancies in the United States are unplanned 6

There are no adequate and well-controlled studies for any HAE treatment in pregnant women. RUCONEST is not indicated for prophylaxis.
*Data cannot definitively establish the absence of any risk because of the small sample size and nonrandomized study design.

In a retrospective case collection study, 14 pregnant women aged 17-37 years with HAE received RUCONEST at 50 U/kg IV (max 4200 U) for acute attacks or prophylaxis during pregnancy 1 *

  • All women delivered at full term without complications
  • RUCONEST is plasma-free and eliminates the risk of human bloodborne pathogen transmission
  • No adverse events related to RUCONEST were reported during the pregnancy period

The right dose matters

dose for IV injection IV Icon
Volume (mL) of reconstituted
solution (150 U/mL) to be
Bottle Icon
<84 kg 50 U/kg Body weight in
kg divided by 3
>84 kg 4200 U (2 vials) 28 mL
  • Do not exceed 4200 U per dose
  • No more than 2 doses should be administered within a 24-hour period

RUCONEST raised functional C1-INH levels to normal in >94% of patients 4

RUCONEST allows appropriately trained participants and their caregivers to treat attacks at home or on the go

Intravenous injection that can be self-administered in just 5 minutes. 1

  • Maximum dose of 4200 U (2 vials) for patients weighing 84 kg

Dosing calculator

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Science of HAE

Hear Dr. Michael Manning talk about the science of HAE and RUCONEST

HAE challenges

Learn about two common challenges you may experience with HAE patients


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