The Science of HAE Treatment

The Science of HAE & the Importance of C1-INH

  • HAE presents a variety of treatment challenges.
  • In this video, we will explore and examine the existing and emerging science of HAE and the importance of C1 esterase inhibitor (C1-INH). The science of HAE is a culmination of more than 20 years of scientific research.
  • Clinical understanding of the underlying disease process is evolving, providing a greater knowledge base on which to build individualized treatment plans.

HAE Challenges

HAE Challenges

  • Practitioners treating HAE encounter a variety of challenges. In this video, we'll focus on two that you may see in your practice
    • Redosing of acute treatment
    • HAE with "normal" C1 esterase inhibitor (C1-INH)

      There have been no well-controlled prospective studies of C1-INH for the treatment of HAE in people with normal C1-INH lab results. The safety and efficacy of C1-INH replacement therapy in this patient population is unknown.

Delve into the science and HAE challenges

Cascade visualization of HAE

Abbreviation: HAE-nl-C1INH, HAE with normal C1 inhibitor.
Download the Cascade Visualization

Pharming partnered with a world authority on the pathogenesis and treatment of hereditary angioedema (HAE) to develop a visualization of the interconnectedness of the complement, contact activation, and fibrinolysis systems and how their interworkings lead to the symptomatology experienced in HAE attacks.

Use this visualization to explore the role of C1-INH in HAE attacks and potential HAE treatment challenges.

Redosing may prevent your patients from getting back to things that matter.

44% of patients experiencing HAE attacks have to retreat in order to get relief.

*Based on literature, 3-44% of swells needed to be retreated

Treatment with RUCONEST

Let's take a look at a specific C1-INH, RUCONEST, for HAE challenges.

RUCONEST Efficacy and Safety

Science of HAE

Hear Dr. Michael Manning talk about the science of HAE and RUCONEST

HAE challenges

Learn about two common challenges you may experience with HAE patients


See the efficacy and safety of RUCONEST

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